Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by 5 subunit-containing -aminobutyric acid type A receptors
نویسندگان
چکیده
*Institute of Medical Science, Departments of †Anesthesia, §Physiology, and Pharmaceutical Sciences, University of Toronto, Toronto, ON, Canada M5S 1A8; ¶Merck Sharp & Dohme Research Laboratories, Neuroscience Research Center, Terlings Park, Harlow, Essex CM20 2QR, United Kingdom; ‡Department of Pharmacology and Neuroscience, Ninewells Medical School, University of Dundee, Dundee DD1 9SY, United Kingdom; and **Department of Anesthesia, Sunnybrook and Women’s College Health Science Center, Toronto, ON, Canada M4N 3M5
منابع مشابه
Brief Communication Low Ethanol Concentrations Selectively Augment the Tonic Inhibition Mediated by Subunit-Containing GABAA Receptors in Hippocampal Neurons
In central neurons, a tonic conductance is activated by ambient levels of the inhibitory transmitter GABA. Here, we show that in dentate gyrus granule cells, where tonic inhibition is mediated by subunit-containing GABAA receptors, this conductance is augmented by low concentrations (30 mM) of ethanol. In contrast, the tonic inhibition mediated by 5 subunit-containing receptors of CA1 pyramidal...
متن کاملLow ethanol concentrations selectively augment the tonic inhibition mediated by delta subunit-containing GABAA receptors in hippocampal neurons.
In central neurons, a tonic conductance is activated by ambient levels of the inhibitory transmitter GABA. Here, we show that in dentate gyrus granule cells, where tonic inhibition is mediated by delta subunit-containing GABA(A) receptors, this conductance is augmented by low concentrations (30 mM) of ethanol. In contrast, the tonic inhibition mediated by alpha5 subunit-containing receptors of ...
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Glykys, Joseph and Istvan Mody. Hippocampal network hyperactivity following selective reduction of tonic inhibition in GABAA receptor 5 subunit–deficient mice. J Neurophysiol 95: 2796–2807, 2006. First published February 1, 2006; doi:10.1152/jn.01122.2005. Functionally, -aminobutyric acid receptor (GABAR)–mediated inhibition can be classified as phasic (synaptic) and tonic (extrasynaptic). The ...
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Tonic inhibition is thought to dampen the excitability of principal neurons; however, little is known about the role of tonic GABAergic inhibition in interneurons and the impact on principal neuron excitability. In many brain regions, tonic GABAergic inhibition is mediated by extrasynaptic, δ-subunit-containing GABAA receptors (GABAARs). In the present study we demonstrate the importance of GAB...
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GABA(A) receptors (GABA(A)Rs) assembled of different subunits mediate tonic and phasic inhibition in hippocampal neurons. CA1/CA3 pyramidal cells (PCs) predominantly express alpha5 subunits whereas dentate gyrus granule cells (DGGCs) and molecular layer (ML) interneurons predominantly express delta subunits. Both alpha5- and delta-containing GABA(A)Rs mediate tonic inhibition. We have shown pre...
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